What is nuvigil 150 mg

what is nuvigil 150 mg

Mar 04,  · Nuvigil (armodafinil) is a medication that promotes wakefulness. Nuvigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder. Nuvigil may also be used for purposes not listed in this medication guide. Mar 24,  · Nuvigil is a prescription medicine used to treat the symptoms of Obstructive Sleep Apnea, Narcolepsy and Shift Work Sleep Disorder. Nuvigil may be used alone or with other medications. Nuvigil belongs to a class of drugs called Stimulants. It is not known if Nuvigil is safe and effective in children.

Nuvigil Armodafinil mg is currently FDA-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy what is nuvigil 150 mg, and shift work disorder. It is commonly used off-label to treat attention deficit nuivgil disorder, chronic fatigue syndrome, and major depressive disorder. It has been shown to improve iw in air traffic controllers.

Nuvigil Armodafinil mg is approved by the U. FDA for the treatment of narcolepsy and shift work sleep disorder, and as an adjuvant therapy for obstructive sleep apnea.

For narcolepsy and obstructive sleep apnea, armodafinil is taken as a once daily mg or mg dose in the morning.

For shift work sleep disorder, mg of armodafinil nuviggil taken one hour prior to starting work. Slow dose titration is needed to mitigate some side effects. For people who have stopped what is the best alcohol for a diabetes to drink, Naltrexone reduces the craving for alcohol which many alcohol dependent people experience when they quit drinking.

It is not fully understood how Naltrexone works to reduce the craving for alcohol, but some scientists believe it works by affecting the neural pathways in nubigil brain where the neurotransmitter dopamine is found.

Nuvigil armodafinil is a single-isomer of modafini. The exact mechanism of action is unknown. Armodafinil belongs to a class of drugs known as eugeroics, which are stimulants that provide long-lasting mental arousal. Armodafinil is 1150 a direct- or indirect-acting dopamine receptor agonist.

However, in vitro, both armodafinil and modafinil bind to the dopamine transporter and inhibit dopamine reuptake.

In placebo-controlled studies, the most commonly observed side effects were headache, nausea, dizziness, and insomnia. Armodafinil is the R-enantiomer of modafinil which nuvigkl a mixture of the Rand S-enantiomers. The chemical name for armodafinil is 2-[ R - diphenylmethyl sulfinyl]acetamide.

Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. Unvigil to content. Nuvigil Armodafinil mg quantity. Mechanism of Action For people who have stopped drinking, Naltrexone reduces the craving for alcohol which many alcohol dependent people experience when they quit drinking. Adverse effects In placebo-controlled studies, the most commonly observed side effects were headache, nausea, dizziness, and insomnia. Nuvigil Armodafinil mg pills, pills, pills, pills.

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What is Nuvigil?

benefit beyond that of the mg/day dose [see Clinical Pharmacology () and Clinical Studies (, )]. Dosage in Shift Work Disorder (SWD) The recommended dosage of NUVIGIL for patients with SWD is mg taken orally once a day as a single dose approximately 1 . What is Nuvigil (Armodafinil) mg? Nuvigil (Armodafinil) mg is currently FDA-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is commonly used off-label to treat attention deficit hyperactivity disorder, chronic fatigue syndrome, and major depressive disorder. ARMODAFINIL is used to treat excessive sleepiness caused by certain sleep disorders. This includes narcolepsy, sleep apnea, and shift work sleep disorder. The lowest GoodRx price for the most common version of generic Nuvigil is around $, 91% off the average retail price of $

Generic Name: armodafinil Dosage Form: tablet. Medically reviewed by Drugs. Last updated on March 1, Nuvigil is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea OSA , narcolepsy, or shift work disorder SWD. In OSA, Nuvigil is indicated to treat excessive sleepiness and not as treatment for the underlying obstruction. If continuous positive airway pressure CPAP is the treatment of choice for a patient, a maximal effort to treat with CPAP for an adequate period of time should be made prior to initiating Nuvigil for excessive sleepiness.

The recommended dosage of Nuvigil for patients with OSA or narcolepsy is mg to mg taken orally once a day as a single dose in the morning. The recommended dosage of Nuvigil for patients with SWD is mg taken orally once a day as a single dose approximately 1 hour prior to the start of their work shift. In patients with severe hepatic impairment, the dosage of Nuvigil should be reduced [see Use in Specific Populations 8.

Consideration should be given to the use of lower doses and close monitoring in geriatric patients [see Use in Specific Populations 8. Nuvigil is contraindicated in patients with known hypersensitivity to modafinil or armodafinil or its inactive ingredients [see Warnings and Precautions 5.

Serious rash requiring hospitalization and discontinuation of treatment has been reported in association with the use of Nuvigil armodafinil or modafinil the racemic mixture of S- and R-enantiomers. Nuvigil has not been studied in pediatric patients in any setting and is not approved for use in pediatric patients for any indication. In clinical trials of modafinil, the incidence of rash resulting in discontinuation was approximately 0. Several of the cases were associated with fever and other abnormalities e.

The median time to rash that resulted in discontinuation was 13 days. No such cases were observed among pediatric patients who received placebo. Skin and mouth sores, blistering, and ulceration have been reported with modafinil and Nuvigil in the postmarketing setting. Recurrence of signs and symptoms of serious dermatologic reactions following rechallenge has been reported in some cases. Rare cases of serious or life-threatening rash, including SJS and toxic epidermal necrolysis TEN , have been reported in adults and children in worldwide postmarketing experience with modafinil and Nuvigil.

There are no factors, including duration of therapy, that are known to predict the risk of occurrence or the severity of rash associated with modafinil or Nuvigil.

In cases where the time to onset was reported, serious rash occurred 1 day to 2 months after initiation of treatment, but isolated cases of serious dermatologic reactions have been reported with symptoms beginning after prolonged treatment e. Although benign rashes also occur with Nuvigil, it is not possible to reliably predict which rashes will prove to be serious. Accordingly, Nuvigil should be discontinued at the first sign of rash, skin or mouth sores, or blistering or ulceration, unless the rash is clearly not drug-related.

Discontinuation of treatment may not prevent a rash from becoming life-threatening or permanently disabling or disfiguring. Eosinophilia is often present. This disorder is variable in its expression, and other organ systems not noted here may be involved. It is important to note that early manifestations of hypersensitivity e.

One fatal case of DRESS that occurred in close temporal association 3 weeks with the initiation of Nuvigil treatment has been reported in the postmarketing setting. In addition, multi-organ hypersensitivity reactions, including at least one fatality in postmarketing experience, have occurred in close temporal association median time to detection 13 days; range to the initiation of modafinil. Although there have been a limited number of reports, multi-organ hypersensitivity reactions may result in hospitalization or be life-threatening.

If a multi-organ hypersensitivity reaction is suspected, Nuvigil should be discontinued. Although there are no case reports to indicate cross-sensitivity with other drugs that produce this syndrome, the experience with drugs associated with multi-organ hypersensitivity would indicate this to be a possibility.

Angioedema and hypersensitivity with rash, dysphagia, and bronchospasm , were observed with Nuvigil. Patients should be advised to discontinue therapy and immediately report to their physician any signs or symptoms suggesting angioedema or anaphylaxis e. Patients with abnormal levels of sleepiness who take Nuvigil should be advised that their level of wakefulness may not return to normal. Patients with excessive sleepiness, including those taking Nuvigil, should be frequently reassessed for their degree of sleepiness and, if appropriate, advised to avoid driving or any other potentially dangerous activity.

Prescribers should also be aware that patients may not acknowledge sleepiness or drowsiness until directly questioned about drowsiness or sleepiness during specific activities.

In pre-approval narcolepsy, OSA and SWD controlled trials of Nuvigil, anxiety, agitation, nervousness, and irritability were reasons for treatment discontinuation more often in patients on Nuvigil compared to placebo Nuvigil 1.

Depression was also a reason for treatment discontinuation more often in patients on Nuvigil compared to placebo Nuvigil 0. Cases of suicidal ideation were observed in clinical trials. Caution should be exercised when Nuvigil is given to patients with a history of psychosis, depression, or mania.

If psychiatric symptoms develop in association with Nuvigil administration, consider discontinuing Nuvigil. Psychiatric adverse reactions have been reported in patients treated with modafinil. Modafinil and Nuvigil armodafinil are very closely related. Therefore, the incidence and type of psychiatric symptoms associated with Nuvigil are expected to be similar to the incidence and type of these events with modafinil.

Postmarketing adverse reactions associated with the use of Nuvigil, some of which have resulted in hospitalization, have included mania, delusions, hallucinations, suicidal ideation, and aggression. Many, but not all, patients who developed psychiatric adverse reactions had a prior psychiatric history.

In these cases, reported Nuvigil total daily doses ranged from 50 mg to mg, which includes doses below and above the recommended dosages. Although Nuvigil has not been shown to produce functional impairment, any drug affecting the central nervous system CNS may alter judgment, thinking or motor skills. Patients should be cautioned about operating an automobile or other hazardous machinery until it is reasonably certain that Nuvigil therapy will not adversely affect their ability to engage in such activities.

In clinical studies of modafinil, cardiovascular adverse reactions, including chest pain, palpitations, dyspnea and transient ischemic T-wave changes on ECG were observed in three subjects in association with mitral valve prolapse or left ventricular hypertrophy. It is recommended that Nuvigil tablets not be used in patients with a history of left ventricular hypertrophy or in patients with mitral valve prolapse who have experienced the mitral valve prolapse syndrome when previously receiving CNS stimulants.

Findings suggestive of mitral valve prolapse syndrome include but are not limited to ischemic ECG changes, chest pain, or arrhythmia. If new onset of any of these findings occurs, consider cardiac evaluation. There was also a slightly greater proportion of patients on Nuvigil requiring new or increased use of antihypertensive medications 2.

There was a small, but consistent, average increase in pulse rate over placebo in pre-approval controlled trials. This increase varied from 0. Increased monitoring of heart rate and blood pressure may be appropriate in patients on Nuvigil. Caution should be exercised when prescribing Nuvigil to patients with known cardiovascular disease. The following serious adverse reactions are described below and elsewhere in the labeling:.

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Nuvigil has been evaluated for safety in over 1, patients with excessive sleepiness associated with OSA, SWD, and narcolepsy. The adverse reaction profile was similar across the studies. See Table 2 for additional information. Clinical chemistry, hematology, and urinalysis parameters were monitored in the studies.

Mean plasma levels of gamma glutamyltransferase GGT and alkaline phosphatase AP were found to be higher following administration of Nuvigil, but not placebo. A single case of mild pancytopenia was observed after 35 days of treatment and resolved with drug discontinuation.

A small mean decrease from baseline in serum uric acid compared to placebo was seen in clinical trials. The clinical significance of this finding is unknown. The following adverse reactions have been identified during post approval use of Nuvigil.

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Gastrointestinal Disorders: Mouth Sores including mouth blistering and ulceration. Dosage adjustment of these drugs should be considered when these drugs are used concomitantly with Nuvigil [see Clinical Pharmacology The effectiveness of steroidal contraceptives may be reduced when used with Nuvigil and for one month after discontinuation of therapy. Alternative or concomitant methods of contraception are recommended for patients taking steroidal contraceptives e.

Blood levels of cyclosporine may be reduced when used with Nuvigil. Monitoring of circulating cyclosporine concentrations and appropriate dosage adjustment for cyclosporine should be considered when used concomitantly with Nuvigil. Elimination of drugs that are substrates for CYP2C19 e.

Dose reduction of these drugs may be required when these drugs are used concomitantly with Nuvigil. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Nuvigil during pregnancy. Healthcare providers are encouraged to register pregnant patients, or pregnant women may enroll themselves in the registry by calling Limited available data on armodafinil use in pregnant women are insufficient to inform a drug associated risk of adverse pregnancy outcomes.

Intrauterine growth restriction and spontaneous abortion have been reported in association with armodafinil and modafinil. Although the pharmacology of armodafinil is not identical to that of the sympathomimetic amines, armodafinil shares some pharmacologic properties with this class [see Clinical Pharmacology Some sympathomimetics have been associated with intrauterine growth restriction and spontaneous abortions. In animal reproduction studies of armodafinil R-modafinil and modafinil a mixture of R- and S-modafinil conducted in pregnant rats armodafinil, modafinil and rabbits modafinil during organogenesis, evidence of developmental toxicity increased embryofetal and offspring mortality, decreased fetal growth was observed at clinically relevant plasma exposures.

All pregnancies have a background risk of birth defects, loss, or other adverse outcomes. The estimated background risk of major birth defects and miscarriage for the indicated populations is unknown. In the U. No effects on postnatal developmental and neurobehavioral parameters were observed in surviving offspring. There are no data on the presence of armodafinil or its metabolites in human milk, the effects on the breastfed infant, or the effect of this drug on milk production.

Modafinil was present in rat milk when animals were dosed during the lactation period. The effectiveness of hormonal contraceptives may be reduced when used with Nuvigil and for one month after discontinuation of therapy. Advise women who are using a hormonal method of contraception to use an additional barrier method or an alternative non-hormonal method of contraception during treatment with Nuvigil and for one month after discontinuation of Nuvigil treatment [see Drug Interactions 7 and Clinical Pharmacology Safety and effectiveness in pediatric patients have not been established.

Serious rash has been seen in pediatric patients receiving modafinil [see Warnings and Precautions 5. In elderly patients, elimination of armodafinil and its metabolites may be reduced as a consequence of aging.

Therefore, consideration should be given to the use of lower doses and close monitoring in this population [see Dosage and Administration 2.

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